The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2020
Filed:
Nov. 29, 2016
Northwestern University, Evanston, IL (US);
The Board of Trustees of the University of Illinois, Urbana, IL (US);
Michael Christopher Jewett, Evanston, IL (US);
Do Soon Kim, Evanston, IL (US);
Erik D. Carlson, Chicago, IL (US);
Alexander S. Mankin, River Forest, IL (US);
Cedric Orelle, Chicago, IL (US);
Teresa Szal, Forest Park, IL (US);
Anne E. d'Aquino, Evanston, IL (US);
Northwestern University, Evanston, IL (US);
The Board of Trustees of the University of Illinois, Urbana, IL (US);
Abstract
An engineered ribosome that includes a tethered subunit arrangement is disclosed, in which the engineered ribosome supports translation of a sequence defined polymer. Methods for making and using the engineered ribosome are also disclosed, including a method for preparing a sequence defined polymer using the engineered ribosome and a method for preparing a sequence defined polymer using the engineered ribosome in a two-protein translation system. The engineered ribosomes may be utilized in methods for incorporating unnatural amino acids into a sequence defined polymer. Also disclosed are optimized polynucleotide sequences for use as tethers and Shine-Dalgarno/anti-Shine-Dalgarno sequences.