The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 10, 2020
Filed:
Aug. 27, 2019
Applicants:
National Health Research Institutes, Miaoli County, TW;
Academia Sinica, Taipei, TW;
Inventors:
Chih-Hao Chen, Taipei, TW;
Chuan Shih, Carmel, IN (US);
Chiung-Tong Chen, Taipei, TW;
Hwei-Jiung Wang, Taipei, TW;
Kai-Fa Huang, New Taipei, TW;
Assignees:
National Health Research Institutes, Miaoli County, TW;
Academia Sinica, Taipei, TW;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 417/14 (2006.01); C07D 403/14 (2006.01); C07D 413/14 (2006.01); A61P 25/28 (2006.01); C07D 409/14 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 417/14 (2013.01); A61P 25/28 (2018.01); C07D 403/14 (2013.01); C07D 413/14 (2013.01); A61K 45/06 (2013.01); C07D 409/14 (2013.01);
Abstract
Benzimidazole compounds of formula (I), shown below, are disclosed. The compounds are potent human glutaminyl cyclase inhibitors. Also disclosed is a pharmaceutical composition containing one of these compounds and a pharmaceutical acceptable carrier, as well as a method of treating Alzheimer's disease or Huntington's disease by administering to a subject in need thereof an effective amount of such a compound.