The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10577387 B1

Date of Patent:

Mar. 03, 2020

Filed:

Aug. 09, 2018

Platinum (ii) complexes containing n-heterocyclic carbene ligand and pincer ligands, synthesis, and their applications in cancer treatment

Applicant:

The University of Hong Kong, Hong Kong, CN;

Inventors:

Chi Ming Che, Mid-Level, HK;

Sin Ki Fung, New Territories, HK;

Tian Feng Chen, Guangzhou, CN;

Assignee:

THE UNIVERSITY OF HONG KONG, Hong Kong, CN;

Attorney:

Leason Ellis LLP

Primary Examiner:

Anna Pagonakis

Int. Cl.

CPC ...

C07F 15/00 (2006.01); A61P 35/00 (2006.01); G01N 33/574 (2006.01); G01N 21/64 (2006.01);

U.S. Cl.

CPC ...

C07F 15/0086 (2013.01); A61P 35/00 (2018.01); G01N 21/6458 (2013.01); G01N 21/6486 (2013.01); G01N 33/57415 (2013.01);

Abstract

Provided herein is a method of synthesis of Pt(II) complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Pt(II) complexes. Also provided is a method of detecting the Pt(II) complex in a biological system. Also provided is a method of making the Pt(II) complex The Pt(II) complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, and inhibition of tumor growth in vivo.

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