The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 03, 2020
Filed:
Nov. 27, 2017
Applicant:
Board of Regents of the University of Texas System, Austin, TX (US);
Inventors:
Jef DeBrabander, Flower Mound, TX (US);
Jerry W. Shay, Dallas, TX (US);
Wentian Wang, Irving, TX (US);
Assignee:
The Board of Regents of the University of Texas System, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 413/04 (2006.01); C07D 417/14 (2006.01); C07D 453/02 (2006.01); C07D 211/96 (2006.01); C07D 471/08 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); C07D 211/96 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 413/04 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 453/02 (2013.01); C07D 471/08 (2013.01); C12N 5/0679 (2013.01); C12N 2510/04 (2013.01);
Abstract
The described invention provides small molecule anti-cancer compounds that selectively target and inhibit measurable biological activity of truncated APC proteins, an immortalized Human Colonic Epithelial Cell (HCEC) model, and pharmaceutical compositions comprising at least one of the small molecule anti-cancer compounds and a pharmaceutically acceptable carrier.