The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 03, 2020
Filed:
Nov. 13, 2017
University of South Carolina, Columbia, SC (US);
Dominic M. Casali, Elgin, SC (US);
Michael A. Matthews, Columbia, SC (US);
University of South Carolina, Columbia, SC (US);
Abstract
A system and method for removing residual glutaraldehyde from a natural polymer scaffold crosslinked with glutaraldehyde is provided. The system includes a cleaning solution comprising carbon dioxide and one or more polar solvents and an environmental chamber that can include and a treatment chamber. The environmental chamber is maintained at a temperature greater than 31.1° C. and the carbon dioxide is maintained at a pressure greater than 7.38 megapascals to form supercritical carbon dioxide. A crosslinked natural polymer scaffold treated via the glutaraldehyde removal system and method can have a glutaraldehyde content of less than about 3 parts per million. A crosslinked natural polymer scaffold cleaning solution comprising supercritical carbon dioxide and one or more polar solvents is also provided.