The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 25, 2020

Filed:

Aug. 31, 2015
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Jason Imbriglio, Piscataway, NJ (US);

Rui Liang, East Brunswick, NJ (US);

Clare London, Chatham, NJ (US);

Kenneth Marby, San Diego, CA (US);

James Tata, Westfield, NJ (US);

Ming You, Monroe, NJ (US);

Yusheng Xiong, Plainsboro, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 413/12 (2006.01); A61K 31/47 (2006.01); C07D 217/06 (2006.01); A61K 31/16 (2006.01); C07C 13/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/47 (2013.01); A61K 31/16 (2013.01); C07C 13/04 (2013.01); C07D 217/06 (2013.01);
Abstract

The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof. The compounds of formula (I) are inhibitors of diacylglyceride O-acyltransferase 2 ('DGAT2') and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.


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