The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 18, 2020

Filed:

Sep. 29, 2017
Applicant:

Cellagenics B.v., Amsterdam, NL;

Inventors:

Arie Pieter Otte, Amersfoort, NL;

Michel Siep, Rotterdam, NL;

John Antonius Verhees, Wageningen, NL;

Femke Hoeksema, Duivendrecht, NL;

Henricus Johannes Maria Van Blokland, Wijde Wormer, NL;

Assignee:

CellaGenics B.V., Amsterdam, NL;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); C12N 15/67 (2006.01);
U.S. Cl.
CPC ...
C12N 15/85 (2013.01); C12N 15/67 (2013.01);
Abstract

The present invention relates to nucleic acid fragments and constructs comprising genomic nucleotide sequences, which are present upstream of Rb1 and p15C that are associated with intergenic transcription, for the production of a gene product of interest in a eukaryotic, preferably mammalian, host cell in the presence of a stringent selectable marker. The invention further relates to host cells comprising the nucleic acid constructs, to methods for generating the host cells and to methods for producing a gene product of interest using the host cells.


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