The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 2019
Filed:
Jan. 12, 2018
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangdong, CN;
Jinyong Wang, Guangdong, CN;
Chengxiang Xia, Guangdong, CN;
Yong Dong, Guangdong, CN;
Tongjie Wang, Guangdong, CN;
Xiaofei Liu, Guangdong, CN;
Juan Du, Guangdong, CN;
Yang Geng, Guangdong, CN;
Lijuan Liu, Guangdong, CN;
Hongling Wu, Guangdong, CN;
Abstract
The present invention discloses a method for remolding bone marrow microenvironment in a subject having an impaired bone marrow microenvironment, which comprises implanting a composition comprising isolated mesenchymal stromal cells (MSCs) into the bone marrow cavity of the subject. The method of the present invention successfully remolds the bone marrow microenvironment, recovers the normal hematopoiesis of bone marrow, inhibits/delays the pathological process of leukemia and significantly prolongs the survival period. In addition, the method according to the present invention can be used for the treatment of hematologic tumors such as leukemia and aplastic anemia (AA), which is safe and effective but has no side effects.