The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 19, 2019

Filed:

Jun. 28, 2017
Applicants:

Keio University, Minato-ku, JP;

Kabushiki Kaisha Yakult Honsha, Minato-ku, JP;

Inventors:

Yusuke Tanigawara, Shinjuku-ku, JP;

Akito Nishimuta, Shinjuku-ku, JP;

Junya Tsuzaki, Shinjuku-ku, JP;

Hiroyuki Takahashi, Minato-ku, JP;

Assignees:

KEIO UNIVERSITY, Minato-ku, JP;

KABUSHIKI KAISHA YAKULT HONSHA, Minato-ku, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/282 (2006.01); A61K 31/513 (2006.01); G01N 33/574 (2006.01); A61K 45/06 (2006.01); A61K 31/555 (2006.01); A61K 47/18 (2017.01); A61K 47/26 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
G01N 33/57484 (2013.01); A61K 31/282 (2013.01); A61K 31/513 (2013.01); A61K 31/555 (2013.01); A61K 45/06 (2013.01); A61K 47/18 (2013.01); A61K 47/183 (2013.01); A61K 47/26 (2013.01); G01N 33/574 (2013.01); G01N 33/6848 (2013.01); G01N 2560/00 (2013.01); G01N 2570/00 (2013.01); G01N 2800/52 (2013.01); Y10T 436/143333 (2015.01); Y10T 436/147777 (2015.01); Y10T 436/163333 (2015.01); Y10T 436/173845 (2015.01); Y10T 436/201666 (2015.01);
Abstract

To provide an anti-cancer agent sensitivity determination marker, which marker can determine whether or not the patient has a therapeutic response to the anti-cancer agent, and novel cancer therapeutic means employing the marker. The anti-cancer agent sensitivity determination marker, the anti-cancer agent including oxaliplatin or a salt thereof and fluorouracil or a salt thereof, contains one or more substances selected from among an amino-acid-metabolism-related substance, a nucleic-acid-metabolism-related substance, a substance in the pentose phosphate pathway, a substance in the glycolytic pathway, a substance in the TCA cycle, a polyamine-metabolism-related substance, 7,8-dihydrobiopterin, 6-phosphogluconic acid, butyric acid, triethanolamine, 1-methylnicotinamide, NADH, NAD, and a substance involved in the metabolism of any of these substances.


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