The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 12, 2019

Filed:

Oct. 08, 2015
Applicant:

Dsm Ip Assets B.v., Heerlen, NL;

Assignee:

DSM IP ASSETS B.V., Heerlen, NL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 19/56 (2006.01); C12N 15/52 (2006.01); A23L 27/30 (2016.01); C12P 19/18 (2006.01);
U.S. Cl.
CPC ...
C12P 19/56 (2013.01); A23L 27/33 (2016.08); A23L 27/36 (2016.08); C12N 15/52 (2013.01); C12P 19/18 (2013.01); C12Y 106/02004 (2013.01); C12Y 114/13078 (2013.01); C12Y 114/13079 (2013.01); C12Y 204/00 (2013.01); C12Y 402/03019 (2013.01); C12Y 505/01013 (2013.01); A23V 2002/00 (2013.01);
Abstract

The present invention relates to a method for increasing the degree of glycosylation of a composition comprising steviol glycosides, which method comprises: a. contacting said composition comprising steviol glycosides with a recombinant microorganism, a cell free extract derived from such a microorganism or an enzyme preparation derived from either thereof; and b. thereby to increase the degree of glycosylation of the composition comprising steviol glycosides, wherein the recombinant microorganism comprises one or more nucleotide sequence(s) encoding: a polypeptide having ent-copalyl pyrophosphate synthase activity; a polypeptide having ent-Kaurene synthase activity; a polypeptide having ent-Kaurene oxidase activity; a polypeptide having kaurenoic acid 13-hydroxylase activity; and one or more polypeptides having UDP-glucosyltransferase activity whereby expression of the nucleotide sequence(s) confer(s) on the microorganism the ability to produce at least one steviol glycoside. The present invention also relates to a composition comprising steviol glycosides obtainable by such a method.


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