The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 2019
Filed:
Feb. 22, 2016
Research Institute AT Nationwide Children's Hospital, Columbus, OH (US);
Ohio State Innovation Foundation, Columbus, OH (US);
Mark E. Peeples, Bexley, OH (US);
Jianrong Li, Dublin, OH (US);
Hui Cai, Columbus, OH (US);
Rongzhang Wang, Columbus, OH (US);
Ohio State Innovation Foundation, Columbus, OH (US);
Research Institute at Nationwide Children's Hospital, Columbus, OH (US);
Abstract
Described herein are mutantcomprising a nucleotide sequence which encodes a mutated zinc binding motif in an M2-1 protein of the, wherein the zinc binding motif is mutated relative to wild-type. The mutantdescribed herein grow to high titer in cell culture, are genetically stable, are attenuated in vitro and in vivo, and are highly immunogenic. Also described herein are vaccines and vaccine compositions comprising the live attenuated mutant. Vaccine compositions can further comprise a pharmaceutically acceptable carrier, vehicle, excipient, and/or adjuvant. Methods for inducing a protective immune response in a subject against ainfection are also described and disclosed. The vaccine compositions and methods described herein can be used to preventand respiratory syncytial virus infection in humans, respiratory syncytial virus infection in cattle, avianinfection in various avian species, and pneumonia virus of mice in rodents.