The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 2019
Filed:
Sep. 23, 2018
Wave Life Sciences Ltd., Singapore, SG;
David Charles Donnell Butler, Medford, MA (US);
Sethumadhavan Divakaramenon, Lexington, MA (US);
Christopher J. Francis, Arlington, MA (US);
Maria David Frank-Kamenetsky, Brookline, MA (US);
Naoki Iwamoto, Brighton, MA (US);
Genliang Lu, Winchester, MA (US);
Subramanian Marappan, Acton, MA (US);
Meena, Belmont, MA (US);
Chandra Vargeese, Schwenksville, PA (US);
Gregory L. Verdine, Boston, MA (US);
Hailin Yang, West Roxbury, MA (US);
Jason Jingxin Zhang, Walpole, MA (US);
WAVE LIFE SCIENCES LTD., Singapore, SG;
Abstract
Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.