IDiyas

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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10435400 B1

PDFFull Text
Date of Patent:
Oct. 08, 2019

Filed:

Feb. 13, 2015

2,4-disubstituted phenylene-1,5-diamine derivatives and applications thereof, and pharmaceutical compositions and pharmaceutically acceptable compositions prepared therefrom

Applicants:

Shanghai Haiyan Pharmaceutical Technology Co., Ltd., Shanghai, CN;

Yangtze River Pharmaceutical Group Co., Ltd., Jiangsu, CN;

Inventors:

Jiong Lan, Shanghai, CN;

Yunzhou Jin, Shanghai, CN;

Fusheng Zhou, Shanghai, CN;

Jing Xie, Shanghai, CN;

Sida Shen, Shanghai, CN;

Yi Hu, Shanghai, CN;

Wei Liu, Shanghai, CN;

Qiang Lv, Shanghai, CN;

Assignees:

SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD., Shanghai, CN;

YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD., Jiangsu, CN;

Attorney:

Mintz Levin Cohn Ferris Glovsky and Popeo PC

Primary Examiner:

Andrew D Kosar

Assistant Examiner:

John S Kenyon

Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 471/04 (2006.01); A61K 31/506 (2006.01); A61K 31/53 (2006.01); A61K 31/5377 (2006.01); A61K 31/5386 (2006.01); A61K 31/553 (2006.01); A61K 45/06 (2006.01); C07D 239/48 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 491/08 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/506 (2013.01); A61K 31/53 (2013.01); A61K 31/5377 (2013.01); A61K 31/5386 (2013.01); A61K 31/553 (2013.01); A61K 45/06 (2013.01); C07D 239/48 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 491/08 (2013.01);
Abstract

The present invention provides a class of 2,4-substituted phenylene-1,5-diamine derivatives, having an inhibiting effect on EGFR tyrosine kinases, and pharmaceutically acceptable salt, stereoisomer, solvate or prodrug of said derivatives. See the description for the definition of each group in the formula. In addition, the present invention also discloses pharmaceutical compositions, pharmaceutically acceptable compositions and applications thereof.

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