The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 08, 2019

Filed:

Jul. 21, 2011
Applicants:

Joseph M. Fox, Landenberg, PA (US);

Matthew Hassink, Wilmington, DE (US);

Melissa Blackman, Waltham, MA (US);

Zibo LI, Logan, UT (US);

Peter S. Conti, Pasadena, CA (US);

Ramajeyam Selvaraj, Newark, DE (US);

Inventors:

Joseph M. Fox, Landenberg, PA (US);

Matthew Hassink, Wilmington, DE (US);

Melissa Blackman, Waltham, MA (US);

Zibo Li, Logan, UT (US);

Peter S. Conti, Pasadena, CA (US);

Ramajeyam Selvaraj, Newark, DE (US);

Assignees:

University of Delaware, Newark, DE (US);

University of Southern California, Los Angeles, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61M 36/14 (2006.01); A61K 51/04 (2006.01); C07D 257/08 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01);
U.S. Cl.
CPC ...
A61K 51/0497 (2013.01); C07D 257/08 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01);
Abstract

A Diels-Alder adduct of a trans-cyclooctene with a tetrazine is provided, wherein the adduct bears a substituent labeled with a radionuclide. A method of producing a PET or other image of an organ in an animal or human includes forming the Diels-Alder adduct in the animal or human. Trans-cyclooctenes and tetrazines suitable for preparing the adducts are provided.


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