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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10428131 B1

PDFFull Text
Expired
Date of Patent:
Oct. 01, 2019

Filed:

Aug. 11, 2016

Gitrl fusion proteins comprising a human coronin 1a derived trimerization domain

Applicant:

Medimmune Limited, Cambridge, GB;

Inventors:

Ross Anthony Stewart, Cambridge, GB;

Natalie Jo Tigue, Cambridge, GB;

Lesley Lynn Young, Cambridge, GB;

Daniel Ramsay Higazi, Cambridge, GB;

Lisa Bamber, Cambridge, GB;

Sudharsan Sridharan, Cambridge, GB;

Rebecca Leyland, Cambridge, GB;

Nicholas Mason Durham, Gaithersburg, MD (US);

Assignee:

MEDIMMUNE LIMITED, Cambridge, GB;

Attorney:

McDonnell Boehnen Hulbert & Berghoff LLP

Primary Examiner:

Elly-Gerald Stoica

Int. Cl.
CPC ...
C07K 14/525 (2006.01); C07K 14/705 (2006.01); A61K 38/19 (2006.01); A61K 45/06 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/525 (2013.01); A61K 38/191 (2013.01); A61K 45/06 (2013.01); C07K 14/70575 (2013.01); C07K 16/00 (2013.01); C07K 16/2878 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/622 (2013.01); C07K 2317/75 (2013.01); C07K 2319/30 (2013.01); C07K 2319/35 (2013.01); C07K 2319/73 (2013.01); C07K 2319/735 (2013.01);
Abstract

The disclosure provides GITRL fusion polypeptide subunits comprising an IgG Fc domain, a trimerization domain, and the receptor binding domain of GITR ligand, where the fusion polypeptide subunits can self-assemble into hexameric proteins. Also provided are methods of making fusion polypeptide subunits and hexameric proteins, and methods of use, e.g., treatment of cancer.

Find Patent Forward Citations

Stewart, Ross. (2019). Gitrl fusion proteins comprising a human coronin 1a derived trimerization domain (U.S. Patent No. 10428131). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10428131

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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