The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 24, 2019

Filed:

Mar. 10, 2014
Applicants:

Jianwei Che, San Diego, CA (US);

Jennifer Harris, San Diego, CA (US);

Hsin-i Hsieh, San Diego, CA (US);

Jie LI, San Diego, CA (US);

Jun Liu, San Diego, CA (US);

Nicholas NG, San Diego, CA (US);

Inventors:

Jianwei Che, San Diego, CA (US);

Jennifer Harris, San Diego, CA (US);

Hsin-I Hsieh, San Diego, CA (US);

Jie Li, San Diego, CA (US);

Jun Liu, San Diego, CA (US);

Nicholas Ng, San Diego, CA (US);

Assignee:

Novartis AG, Basel, CH;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6886 (2018.01); A61K 31/444 (2006.01); A61K 31/497 (2006.01); A61K 31/501 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); A61K 31/444 (2013.01); A61K 31/497 (2013.01); A61K 31/501 (2013.01); G01N 33/57407 (2013.01); G01N 33/57484 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01); G01N 2800/52 (2013.01);
Abstract

The invention provides methods of monitoring differential gene expression of biomarkers to determine patient sensitivity to Wnt inhibitor, methods of determining the sensitivity of a cell to an Wnt inhibitor by measuring biomarkers, methods of screening for candidate Wnt inhibitor, Wnt inhibitor for use in head and neck squamous cell carcinoma.


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