The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2019
Filed:
Aug. 20, 2018
Saol International Limited, Hamilton, BM;
Michael C. Schmitz, Prior Lake, MN (US);
Corinne Dominguez, Tolochenaz, CH;
Thomas E. Keene, Golden Valley, MN (US);
Deanna S. Lane, Golden Valley, MN (US);
Lanchi T. Le, Lake Elmo, MN (US);
Jianwei Li, Woodbury, MN (US);
Ngoc T. Lu, Maple Grove, MN (US);
Carmen E. Snaza, Maplewood, MN (US);
SAOL INTERNATIONAL LIMITED, Hamilton, BM;
Abstract
Methods for preparing sterilized baclofen solutions include adjusting the pH to below a desired pH, and steam sterilizing the solution with adjusted pH, which results in the solution having the desired pH. Such solutions may also have low concentrations of 4-CPP. Injectable baclofen solutions having greater than 2 mg/mL baclofen include between 5 mM and 25 mM of a phosphate or sulfate species. The solution has an ionic strength equivalent of about 1.5 M NaCl. The present application also provides baclofen formulations for use in treating spasticity, brain injury, cerebral palsy, spinal cord injury, cervical injury, multiple sclerosis, thoracic injury, or withdrawal symptoms.