The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2019
Filed:
Sep. 04, 2015
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);
Peter Kwong, Washington, DC (US);
Marie Pancera, Seattle, WA (US);
Tongqing Zhou, Boyds, MD (US);
Ivelin Georgiev, Nashville, TN (US);
Michael Gordon Joyce, Bethesda, MD (US);
Priyamvada Acharya, Fort Lee, NJ (US);
Jason Gorman, Washington, DC (US);
Yongping Yang, Potomac, MD (US);
Aliaksandr Druz, Germantown, MD (US);
Guillaume Stewart-Jones, Bethesda, MD (US);
Rita Chen, Bethesda, MD (US);
Gwo-Yu Chuang, Beethesda, MD (US);
Ulrich Baxa, Frederick, MD (US);
John Mascola, Rockville, MD (US);
Rebecca Lynch, Washington, DC (US);
Baoshan Zhang, Bethesda, MD (US);
Cheng Cheng, Rockville, MD (US);
Abstract
HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.