The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 27, 2019

Filed:

Nov. 16, 2012
Applicant:

Board of Regents, the University of Texas System, Austin, TX (US);

Inventors:

Laurence J. Neil Cooper, Houston, TX (US);

Hiroki Torikai, Houston, TX (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/14 (2015.01); A61K 35/17 (2015.01); A61K 39/00 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61K 39/0011 (2013.01); C12N 5/0636 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/5158 (2013.01); C12N 2510/00 (2013.01); Y02A 50/467 (2018.01);
Abstract

The present invention concerns methods and compositions for immunotherapy employing a modified T cell comprising disrupted T cell receptor and/or HLA and comprising a chimeric antigen receptor. In certain embodiments, the compositions are employed allogeneically as universal reagents for 'off-the-shelf treatment of medical conditions such as cancer, autoimmunity, and infection. In particular embodiments, the T cell receptor-negative and/or HLA-negative T cells are generated using zinc finger nucleases, for example.


Find Patent Forward Citations

Cooper, Laurence J. Neil. (2019). Car+ t cells genetically modified to eliminate expression of t-cell receptor and/or hla (U.S. Patent No. 10391126). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10391126

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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