The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 20, 2019
Filed:
Sep. 05, 2014
Inis Biotech Llc, Milford, DE (US);
Consejo Nacional DE Investigaciones Cientificas Y Tecnicas (Conicet), Ciudad Autonoma de Buenos Aires, AR;
Fundacion Instituto Leloir (Fil), Ciudad Autonoma de Buenos Aires, AR;
Asociacion Civil DE Estudios Superiores (Aces), Ciudad Autonoma de Buenos Aires, AR;
Guillermo Daniel Mazzolini, Provincia de Buenos Aires, AR;
Estanislao Peixoto, Ciudad Autonoma de Buenos Aires, AR;
Jorge Aquino, Provincia de Buenos Aires, AR;
Maria C. Atorrasagasti, Ciudad Autonoma de Buenos Aires, AR;
Osvaldo Podhjacer, Ciudad Autonoma de Buenos Aires, AR;
INIS BIOTECH LLC, Milford, Kent County, DE (US);
CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET), Ciudad Autonoma de Buenos Aires, AR;
FUNDACION INSTITUTO LELOIR (FIL), Ciudad Autónoma de Buenos Aires, AR;
ASOCIACION CIVIL DE ESTUDIOS SUPERIORES (ACES), Ciudad Autónoma de Buenos Aires, AR;
Abstract
The invention relates to the identification of Secreted Protein, Acidic and Rich in Cysteine (SPARC) as a new therapeutic target in patients with fulminant hepatitis and allows the development of a strategy destined to protect the liver form damage. The invention relates to the treatment of acute liver failure or fulminant hepatitis by administering to a subject in need thereof an agent that inhibits at least partially the expression of SPARC and/or interferes with its biological function.