The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 20, 2019

Filed:

Sep. 23, 2015
Applicant:

Indiana University Research and Technology Corporation, Indianapolis, IN (US);

Inventors:

Richard D. Dimarchi, Carmel, IN (US);

Binbin Kou, Bloomington, IN (US);

Fa Zhang, Bloomington, IN (US);

John P. Mayer, Indianapolis, IN (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/62 (2006.01); A61K 38/28 (2006.01); A61K 47/54 (2017.01); A61K 47/69 (2017.01); A61K 38/00 (2006.01); A61K 47/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/62 (2013.01); A61K 38/28 (2013.01); A61K 47/54 (2017.08); A61K 47/543 (2017.08); A61K 47/6911 (2017.08); A61K 38/00 (2013.01); A61K 47/00 (2013.01);
Abstract

Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half-lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.


Find Patent Forward Citations

Dimarchi, Richard. (2019). Lipidated amide-based insulin prodrugs (U.S. Patent No. 10385107). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10385107

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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