The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 23, 2019
Filed:
Dec. 21, 2016
Applicant:
Lanzatech New Zealand Limited, Skokie, IL (US);
Inventors:
Shilpa Nagaraju, Skokie, IL (US);
Michael Koepke, Skokie, IL (US);
Assignee:
LANZATECH NEW ZEALAND LIMITED, Auckland, NZ;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 1/21 (2006.01); C12N 9/02 (2006.01); C12P 7/06 (2006.01); C12P 7/16 (2006.01); C12P 7/54 (2006.01); C12P 7/18 (2006.01); C12P 7/04 (2006.01);
U.S. Cl.
CPC ...
C12P 7/065 (2013.01); C12N 9/0067 (2013.01); C12P 7/04 (2013.01); C12P 7/18 (2013.01); C12P 7/54 (2013.01); C12Y 112/07002 (2013.01); Y02E 50/17 (2013.01);
Abstract
The invention provides genetically engineered microorganisms with modified hydrogenase activity and methods related thereto. Typically, the microorganisms are C1-fixing microorganisms with one or more disruptive mutations in a hydrogenase enzyme or a hydrogenase accessory enzyme. The microorganisms may have improved tolerance to toxins, such as acetylene, isocyanide, ammonium, or nitric oxide, improved production of products, such as ethanol, 2,3-butanediol, and isopropanol, and/or improved fixation of carbon, such as carbon derived from CO or CO.