The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2019
Filed:
Oct. 02, 2014
Applicant:
The Trustees of Princeton University, Princeton, NJ (US);
Inventors:
Assignee:
THE TRUSTEES OF PRINCETON UNIVERSITY, Princeton, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C07F 9/6503 (2006.01); C07K 16/44 (2006.01); G01N 33/53 (2006.01);
U.S. Cl.
CPC ...
C07F 9/65036 (2013.01); C07K 16/44 (2013.01); G01N 33/5308 (2013.01); G01N 2800/26 (2013.01);
Abstract
Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs. The invention is based in part on new pHis analogs that are chemically stable and which have been used as haptens and immunogens to generate specific anti-pHis antibodies that bind with high affinity and specificity.