The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 2019
Filed:
Nov. 05, 2015
President and Fellows of Harvard College, Cambridge, MA (US);
Daniel J. Finley, Jamaica Plain, MA (US);
Randall W. King, Brookline, MA (US);
Byung-Hoon Lee, Cambridge, MA (US);
Min Jae Lee, Jamaica Plain, MA (US);
Timothy C. Gahman, Encinitas, CA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Abstract
Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.