The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2019
Filed:
Jul. 10, 2015
Applicant:
Novartis Ag, Basel, CH;
Inventors:
Keith A. Bowman, Harleysville, PA (US);
Noah Gardner, Cambridge, MA (US);
Travis Jeannotte, Nashua, NH (US);
Chandra Vargeese, Schwenksville, PA (US);
Assignee:
Novartis AG, Basel, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/127 (2006.01); C12N 15/88 (2006.01); C12N 15/113 (2010.01); A61K 31/7105 (2006.01); A61K 31/713 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1277 (2013.01); A61K 9/1272 (2013.01); A61K 31/713 (2013.01); A61K 31/7105 (2013.01); A61K 48/0008 (2013.01); A61K 48/0091 (2013.01); C12N 15/113 (2013.01); C12N 15/88 (2013.01); C12N 2310/14 (2013.01); C12N 2320/32 (2013.01);
Abstract
Encapsulated nucleic acid nanoparticles of uniformly small particle size are produced by intersecting one or more nucleic acid streams with one or more lipid streams. The encapsulated nucleic acid nanoparticles include a nucleic acid encapsulated within a lipid nanoparticle host. Uniformly small particle sizes are obtained by intersecting an aqueous nucleic acid stream and a stream of lipids in organic solvent at high linear velocities and with total organic solvent concentrations less than 33%.