The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 25, 2019
Filed:
May. 30, 2017
Applicant:
Wave Life Sciences Ltd., Singapore, SG;
Inventors:
Takeshi Wada, Kashiwa, JP;
Mamoru Shimizu, Uruma, JP;
Assignee:
WAVE LIFE SCIENCES LTD., Singapore, SG;
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C07H 1/00 (2006.01);
U.S. Cl.
CPC ...
C07H 21/00 (2013.01); C07H 1/00 (2013.01);
Abstract
Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein provide backbone-modified nucleic acids in high diasteteomeric purity via an asymmetric reaction of an achiral molecule comprising a chemically stable H-phophonate moiety with a nucleoside/nucleotide.