The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 2019
Filed:
Oct. 06, 2014
The Board of Trustees of the University of Illinois, Urbana, IL (US);
Martin D. Burke, Champaign, IL (US);
Stephen Davis, Westfield, IN (US);
Brice E. Uno, Champaign, IL (US);
Justin Struble, Ballwin, MO (US);
Ian Dailey, Maplewood, MN (US);
Kaitlyn C. Gray, Freeland, MI (US);
David M. Knapp, Washington, DC (US);
Pulin Wang, Austin, TX (US);
Nagarjuna Palyam, Florence, KY (US);
The Board of Trustees of the University of Illinois, Urbana, IL (US);
Abstract
Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3' or C4′ modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.