The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 04, 2019

Filed:

Feb. 18, 2014
Applicant:

Academia Sinica, Taipei, TW;

Inventors:

Chi-Huey Wong, Taipei, TW;

Che Ma, Taipei, TW;

Cheng-Chi Wang, Taipei, TW;

Juine-Ruey Chen, Sansing Township, TW;

Assignee:

Academia Sinica, Taipei, TW;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/145 (2006.01); C12N 7/00 (2006.01); A61K 39/12 (2006.01); C07K 16/10 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/145 (2013.01); A61K 39/12 (2013.01); C07K 16/1018 (2013.01); C12N 7/00 (2013.01); A61K 2039/55505 (2013.01); C07K 2317/76 (2013.01); C12N 2740/11034 (2013.01); C12N 2740/16034 (2013.01); C12N 2760/16122 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/16171 (2013.01); C12N 2770/24134 (2013.01); Y02A 50/386 (2018.01);
Abstract

Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.


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