The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 04, 2019
Filed:
Jul. 26, 2014
Academia Sinica, Taipei, TW;
Chi-huey Wong, La Jolla, CA (US);
Chung-yi Wu, New Taipei, TW;
Hsien-yeh Hsu, Taipei, TW;
Shih-fen Liao, Taipei, TW;
Chi-hui Liang, Taipei, TW;
Chi-Huey Wong, La Jolla, CA (US);
Chung-Yi Wu, New Taipei, TW;
Hsien-Yeh Hsu, Taipei, TW;
Shih-Fen Liao, Taipei, TW;
Chi-Hui Liang, Taipei, TW;
ACADEMIA SINICA, Taipei, TW;
Abstract
Immunogenic compositions, cancer vaccines and methods for treating cancer comprising FMS, the fucose-enriched polysaccharide fraction from Reishi F3, are provided. Compositions comprise fucose-enriched Reishi polysaccharide fraction (FMS) MW=˜35 kDa, wherein the FMS is isolated by size-exclusion chromatography from Reishi F3, and the FMS comprises polysaccharides having primarily a backbone selected from 1,4-mannan and 1,6-α-galactan, wherein the backbone is linked to a terminal fucose-containing side-chain Immunogenic compositions comprising glycolipid adjuvants are provided. Antibodies generated by immunogenic compositions disclosed herein bind cancer cells comprising antigens Globo H, Globo H, Gb3, Gb4, Gb5 (SSEA-3) and SSEA-4 on the cell surface.