The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 21, 2019

Filed:

May. 05, 2017
Applicant:

The Chinese University of Hong Kong, Shatin, HK;

Inventors:

Yuk Ming Dennis Lo, Homantin, CN;

Wai Kwun Rossa Chiu, Shatin, CN;

Kwan Chee Chan, Shatin, CN;

Wenli Zheng, North Augusta, SC (US);

Peiyong Jiang, Shatin, CN;

Jiawei Liao, Tai Po Market, CN;

Assignee:

The Chinese University of Hong Kong, Shatin, New Territories, HK;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G06F 19/22 (2011.01); G16B 30/00 (2019.01); C12Q 1/6809 (2018.01); C12Q 1/6816 (2018.01); C12Q 1/6827 (2018.01); C12Q 1/6869 (2018.01); G06F 19/00 (2018.01); G06F 19/18 (2011.01); G16H 10/40 (2018.01); G16H 50/20 (2018.01); G16H 50/30 (2018.01); G16B 20/00 (2019.01);
U.S. Cl.
CPC ...
G16B 30/00 (2019.02); C12Q 1/6809 (2013.01); C12Q 1/6816 (2013.01); C12Q 1/6827 (2013.01); C12Q 1/6869 (2013.01); G06F 19/00 (2013.01); G06F 19/18 (2013.01); G06F 19/22 (2013.01); G16B 20/00 (2019.02); G16H 10/40 (2018.01); G16H 50/20 (2018.01); G16H 50/30 (2018.01);
Abstract

A classification of a level of cancer in an organism is determined by analyzing a biological sample of the organism. The biological sample comprises clinically-relevant DNA and other DNA. At least some of the DNA is cell-free in the biological sample. An amount of a first set of DNA fragments from the biological sample corresponding to each of a plurality of sizes is measured. A first value of a first parameter is calculated based on the amounts of DNA fragments at the plurality of sizes. The first value is compared to a reference value. A classification of a level of cancer in the organism is determined based on the comparison.


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