The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 21, 2019
Filed:
Jan. 17, 2017
Applicant:
Augusta University Research Institute, Inc., Augusta, GA (US);
Inventors:
Samir N. Khleif, Silver Spring, MD (US);
Mikayel Mkrtichyan, Millbrae, CA (US);
Iryna Lebedyeva, Augusta, GA (US);
Assignee:
Augusta University Research Institute, Inc., Augusta, GA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4709 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4709 (2013.01); A61K 45/06 (2013.01);
Abstract
Methods of selectively inhibiting Akt3 are provided. It has been discovered that 4-[(6-nitroquinolin-4-yl)amino]-N-[4-(pyridin-4-ylamino)phenyl]benzamide selectively inhibits Akt3. Because Akt3 modulates the suppressive function of natural Tregs and the polarization of induced Tregs, 4-[(6-nitroquinolin-4-yl)amino]-N-[4-(pyridin-4-ylamino)phenyl]benzamide can be used for modulating immune responses.