The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 2019
Filed:
Jun. 30, 2015
Applicant:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Inventors:
Assignee:
YEDA RESEARCH AND DEVELOPMENT CO. LTD., Rehovot, IL;
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/06 (2006.01); G01N 33/58 (2006.01); G01N 33/53 (2006.01); C07D 417/06 (2006.01); C07D 417/14 (2006.01); C07F 9/6541 (2006.01); G01N 33/574 (2006.01); G01N 33/573 (2006.01); C09K 11/06 (2006.01);
U.S. Cl.
CPC ...
G01N 33/53 (2013.01); C07D 417/06 (2013.01); C07D 417/14 (2013.01); C07F 9/6541 (2013.01); C07K 7/06 (2013.01); G01N 33/582 (2013.01); C09K 11/06 (2013.01); C09K 2211/1029 (2013.01); C09K 2211/1037 (2013.01); G01N 33/573 (2013.01); G01N 33/574 (2013.01); G01N 2333/918 (2013.01); G01N 2333/91177 (2013.01); G01N 2333/96494 (2013.01);
Abstract
The present invention is directed to fluorescent protein biosensors based on oligonucleotide cross reactive sensor arrays including a selective and a non-selective protein surface binding domain for protein detection. Interaction of different protein isoforms with the sensors of this invention yields a unique optical signature for each protein. The unique optical signature allows differentiating between closely related protein isoforms and diagnosing diseases and disorders associated with the proteins also in biofluids.