The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 30, 2019

Filed:

Oct. 16, 2015
Applicant:

Twist Bioscience Corporation, San Francisco, CA (US);

Inventors:

William Banyai, San Francisco, CA (US);

Bill James Peck, Santa Clara, CA (US);

Andres Fernandez, San Francisco, CA (US);

Siyuan Chen, San Mateo, CA (US);

Pierre Indermuhle, Berkeley, CA (US);

Assignee:

Twist Bioscience Corporation, San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01J 19/00 (2006.01); C12N 15/10 (2006.01); C40B 50/18 (2006.01); C12N 15/66 (2006.01); C12N 15/74 (2006.01); C40B 50/00 (2006.01); C40B 40/06 (2006.01); C40B 50/14 (2006.01); C12N 15/09 (2006.01);
U.S. Cl.
CPC ...
B01J 19/0046 (2013.01); C12N 15/1093 (2013.01); C12N 15/1096 (2013.01); C12N 15/66 (2013.01); C12N 15/74 (2013.01); C40B 50/18 (2013.01); B01J 2219/0059 (2013.01); B01J 2219/00313 (2013.01); B01J 2219/00317 (2013.01); B01J 2219/00378 (2013.01); B01J 2219/00497 (2013.01); B01J 2219/00585 (2013.01); B01J 2219/00587 (2013.01); B01J 2219/00596 (2013.01); B01J 2219/00605 (2013.01); B01J 2219/00612 (2013.01); B01J 2219/00619 (2013.01); B01J 2219/00623 (2013.01); B01J 2219/00637 (2013.01); B01J 2219/00709 (2013.01); B01J 2219/00722 (2013.01); C12N 15/09 (2013.01); C40B 40/06 (2013.01); C40B 50/00 (2013.01); C40B 50/14 (2013.01);
Abstract

Provided herein are devices for the manufacturing of high-quality oligonucleic acids. Longer nucleic acids, e.g., genes, can be synthesized in parallel using microfluidic assemblies described herein. Devices described herein include silicon plates having a plurality of channels in fluid communication with a plurality of microchannels. The number of microchannels and dimensions of the microchannels provide for rapid exchange of chemical exposure during de novo synthesis of oligonucleic acids.


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