The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 23, 2019
Filed:
Jun. 06, 2016
Applicants:
Morten Karsdal, Copenhagen, DK;
Natasha Barascuk Michaelsen, Gentofte, DK;
Per Qvist, Copenhagen, DK;
Inventors:
Morten Karsdal, Copenhagen, DK;
Natasha Barascuk Michaelsen, Gentofte, DK;
Per Qvist, Copenhagen, DK;
Assignee:
Nordic Bioscience A/S, Herlev, DK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 31/00 (2006.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01); C07K 14/775 (2006.01); C12Q 1/37 (2006.01); G01N 33/542 (2006.01); C07K 14/77 (2006.01); C07K 14/78 (2006.01); G01N 33/577 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6878 (2013.01); C07K 14/77 (2013.01); C07K 14/775 (2013.01); C07K 14/78 (2013.01); C12Q 1/37 (2013.01); G01N 33/542 (2013.01); G01N 33/577 (2013.01); G01N 33/6893 (2013.01); G01N 2800/32 (2013.01); G01N 2800/50 (2013.01); G01N 2800/52 (2013.01);
Abstract
Provided is a method of bioassay for the quantification of N- or C-terminal neo-epitope biomarkers formed by cleavage of a CRP, ApoE, lumican, versican, perlecan, decorin, biglycan or elastin by a proteinase. The method includes contacting a biofluid sample with an antibody reactive with the neo-epitope biomarker and determining the level of binding of the antibody to the biomarker in the sample. The assay is predictive of risk of cardiovascular disease events.