The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2019
Filed:
Mar. 12, 2014
The General Hospital Corporation, Boston, MA (US);
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
University of Massachusetts, Boston, MA (US);
Patricia K. Donahoe, Boston, MA (US);
Demetrios Vavvas, Boston, MA (US);
David Pepin, Somerville, MA (US);
Mien Van Hoang, Braintree, MA (US);
Robert H. Brown, Jr., Worcester, MA (US);
Guangping Gao, Worcester, MA (US);
The General Hospital Corporation, Boston, MA (US);
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
University of Massachusetts, Boston, MA (US);
Abstract
The present invention relates to methods to treat a neurodegenerative disease or disorder, e.g., a motor neuron disease in a subject, whereby the subject is administered a recombinant human Mullerian Inhibiting Substance (MIS) protein as disclosed herein, wherein the recombinant human MIS protein comprises a modified Kex cleavage site for increased cleavage. The recombinant human MIS protein can be produced from a pre-proprotein comprising a non-MIS leader sequence or a functional fragment thereof in place of the MIS leader sequence.