The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 2019
Filed:
Apr. 08, 2016
Novartis Ag, Basel, CH;
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Hans Bitter, Cambridge, MA (US);
Jennifer Mary Bordeaux, Carlsbad, CA (US);
Barbara Brannetti, Basel, CH;
Jennifer Brogdon, Cambridge, MA (US);
Naveen Kumar Dakappagari, Carlsbad, CA (US);
Saar Gill, Philadelphia, PA (US);
Steven Highfill, Bethesda, MD (US);
Lu Huang, Cambridge, MA (US);
Carl H. June, Merion Station, PA (US);
Ju Young Kim, Carlsbad, CA (US);
Ming Lei, Cambridge, MA (US);
Na Li, Cambridge, MA (US);
Andreas Loew, Cambridge, MA (US);
Elena Orlando, Cambridge, MA (US);
Marco Ruella, Philadelphia, PA (US);
Thai Tran, Carlsbad, CA (US);
Jimin Zhang, Cambridge, MA (US);
Li Zhou, Cambridge, MA (US);
Novartis AG, Basel, CH;
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.