The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 26, 2019
Filed:
May. 16, 2018
Drexel University, Philadelphia, PA (US);
Baruch S. Blumberg Institute, Doylestown, PA (US);
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Haitao Guo, Carmel, IN (US);
Dawei Cai, Indianapolis, IN (US);
Andrea Cuconati, Oreland, PA (US);
Changhua Ji, Shanghai, CN;
Drexel University, Philadelphia, PA (US);
Baruch S. Blumberg Institute, Doylestown, PA (US);
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Abstract
The present invention relates to methods and uses for screening anti-hepadnaviral substances, wherein the substances are screened for the capacity to inhibit covalently closed circular (ccc) DNA of a hepadnavirus, like hepatitis B virus. The methods and uses take advantage of cells comprising a nucleic sequence encoding a tagged hepadnavirus e antigen, like Hepatitis B virus e antigen (HBeAg). Furthermore, the present invention provides nucleic acid sequences encoding a tagged hepadnavirus e antigen and proteins encoded thereby. Also kits for use in the screening methods are provided.