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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10208073 B1

PDFFull Text
Date of Patent:
Feb. 19, 2019

Filed:

Jan. 18, 2018

Solution comprising the chloride hydrochloride salt of 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-n,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium-(fosnetupitant) and palonosetron hydrochloride in combination with dexamethasone as a neurokinin receptor modulator

Applicant:

Helsinn Healthcare SA, Lugano/Pazzallo, CH;

Inventors:

Luca Fadini, Giubiasco, CH;

Peter Manini, Giubiasco, CH;

Claudio Pietra, Como, IT;

Claudio Giuliano, Como, IT;

Emanuela Lovati, Mendrisio, CH;

Roberta Cannella, Varese, IT;

Alessio Venturini, Varese, IT;

Valentino J Stella, Lawrence, KS (US);

Assignee:

Helsinn Healthcare SA, Lugano/Pazzallo, CH;

Attorney:

Clark G. Sullivan

Primary Examiner:

Douglas M Willis

Int. Cl.
CPC ...
C07D 213/74 (2006.01); C07D 453/02 (2006.01); C07J 9/00 (2006.01); C07F 9/6509 (2006.01); C07D 401/04 (2006.01); A61K 31/496 (2006.01); A61K 31/56 (2006.01); A61K 45/06 (2006.01); C07D 213/89 (2006.01); A61K 31/44 (2006.01); A61K 31/473 (2006.01); A61K 31/675 (2006.01);
U.S. Cl.
CPC ...
C07F 9/650952 (2013.01); A61K 31/44 (2013.01); A61K 31/473 (2013.01); A61K 31/496 (2013.01); A61K 31/56 (2013.01); A61K 31/675 (2013.01); A61K 45/06 (2013.01); C07D 213/74 (2013.01); C07D 213/89 (2013.01); C07D 401/04 (2013.01);
Abstract

Disclosed is a solution comprising the chloride hydrochloride salt of 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium (fosnetupitant) and palonosetron hydrochloride in combination with dexamethasone and its application in methods for preventing acute and delayed nausea and vomiting in a human patient receiving highly emetogenic cancer chemotherapy.

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