The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2019
Filed:
Jun. 27, 2017
Applicant:
Newlink Genetics, Corp., Ames, IA (US);
Inventors:
Mario Mautino, Ankeny, IA (US);
Sanjeev Kumar, Ames, IA (US);
Firoz Jaipuri, Ames, IA (US);
Jesse Waldo, Huxley, IA (US);
Hima Potturi, Ames, IA (US);
Hong Zhuang, Ames, IA (US);
Assignee:
NEWLINK GENETICS CORPORATION, Ames, IA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/285 (2006.01); C07D 209/20 (2006.01); C07C 309/04 (2006.01); C07F 9/6574 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07C 309/20 (2006.01);
U.S. Cl.
CPC ...
C07D 209/20 (2013.01); A61K 31/285 (2013.01); C07C 309/04 (2013.01); C07C 309/20 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07F 9/65742 (2013.01);
Abstract
Presently provided are indoximod prodrug and salt compounds and pharmaceutical compositions comprising salts and prodrugs of indoximod, that produce enhanced plasma concentration and exposure to indoximod compared to direct administration of indoximod, in patients in need of treatment of immunosuppression mediated by the indoleamine-2,3-dioxygenase pathway, such as patients with cancer or chronic infectious diseases.