The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 29, 2019
Filed:
Dec. 30, 2016
Applicant:
Duke University, Durham, NC (US);
Inventors:
Wei Chen, Chapel Hill, NC (US);
Herbert Kim Lyerly, Chapel Hill, NC (US);
Xiu-rong Ren, Durham, NC (US);
Jiangbo Wang, Durham, NC (US);
Hongtao Guo, Durham, NC (US);
Amy Hobeika, Durham, NC (US);
Robert A. Mook, Chapel Hill, NC (US);
Assignee:
Duke University, Durham, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4184 (2006.01); A61K 31/4196 (2006.01); A61K 45/06 (2006.01); C07D 249/08 (2006.01); C07D 235/18 (2006.01);
U.S. Cl.
CPC ...
C07D 249/08 (2013.01); A61K 31/4184 (2013.01); A61K 31/4196 (2013.01); A61K 45/06 (2013.01); C07D 235/18 (2013.01);
Abstract
Compounds and pharmaceutical compositions that down-regulate immune checkpoints such as PD-1, PD-L1 and CTLA-4 are provided. Also provided are methods of treating a disease by down-regulating immune checkpoints such as PD-1, PD-L1 and CTLA-4. The methods are useful for treating cancer and viral infection in a subject.