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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10167451 B1

PDFFull Text
Date of Patent:
Jan. 01, 2019

Filed:

Dec. 22, 2014

Combinational use of mechanical manipulation and programin derivatives to increase oct4, sox2, or nanog expression in fibroblasts

Applicant:

The Chinese University of Hong Kong, Shatin, New Territories, CN;

Inventors:

Kenneth Ka Ho Lee, Hong Kong, CN;

Tommy Lok Man Lo, Hong Kong, CN;

Hoi Hung Cheung, Kowloon, CN;

Wai Yee Chan, Hong Kong, CN;

Assignee:

The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, CN;

Attorney:

Kilpatrick Townsend & Stockton LLP

Primary Examiner:

Titilayo Moloye

Int. Cl.
CPC ...
C12N 5/074 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0696 (2013.01); C12N 2500/40 (2013.01); C12N 2501/999 (2013.01); C12N 2506/1307 (2013.01); C12N 2506/1392 (2013.01); C12N 2527/00 (2013.01);
Abstract

The present invention provides methods and compositions for inducing pluripotency in differentiated mammalian cells. In particular, the methods include mechanically aggregating the cells into discrete masses or embryoid-like bodies and treated them with a small molecule compound. Provided herein are the compositions of the compounds which are derived from programin (e.g., reversine).

Find Patent Forward Citations

Lee, Kenneth Ka Ho. (2019). Combinational use of mechanical manipulation and programin derivatives to increase oct4, sox2, or nanog expression in fibroblasts (U.S. Patent No. 10167451). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10167451

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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