The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 01, 2019
Filed:
Dec. 22, 2014
Applicant:
The Chinese University of Hong Kong, Shatin, New Territories, CN;
Inventors:
Kenneth Ka Ho Lee, Hong Kong, CN;
Tommy Lok Man Lo, Hong Kong, CN;
Hoi Hung Cheung, Kowloon, CN;
Wai Yee Chan, Hong Kong, CN;
Assignee:
The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/074 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0696 (2013.01); C12N 2500/40 (2013.01); C12N 2501/999 (2013.01); C12N 2506/1307 (2013.01); C12N 2506/1392 (2013.01); C12N 2527/00 (2013.01);
Abstract
The present invention provides methods and compositions for inducing pluripotency in differentiated mammalian cells. In particular, the methods include mechanically aggregating the cells into discrete masses or embryoid-like bodies and treated them with a small molecule compound. Provided herein are the compositions of the compounds which are derived from programin (e.g., reversine).