The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 18, 2018
Filed:
Mar. 16, 2016
National Institute of Advanced Industrial Science and Technology, Chiyoda-ku, Tokyo, JP;
Hisashi Narimatsu, Tsukuba, JP;
Jun Hirabayashi, Tsukuba, JP;
Atsushi Kuno, Tsukuba, JP;
Hideki Matsuzaki, Tsukuba, JP;
Yuzuru Ikehara, Tsukuba, JP;
Hiromi Ito, Fukushima, JP;
Yasuhiro Hashimoto, Fukushima, JP;
Keiro Shirotani, Fukushima, JP;
Satoshi Futakawa, Tokyo, JP;
Hajime Arai, Tokyo, JP;
Masakazu Miyajima, Tokyo, JP;
Kazuo Fujihara, Sendai, JP;
Abstract
The purpose of the present invention is to develop: a method for selectively separating a glycoprotein derived from the central nervous system from a body fluid or a central nervous system cell; and a method for searching for an index marker for central nervous system diseases, which utilizes the aforementioned method. A protein derived from the central nervous system, which occurs in a trace amount in a body fluid or a central nervous system cell, can be selectively enriched by a two-stage separation procedure comprising removing a glycoprotein having sialic acid at a non-reducing terminal thereof from the body fluid or the central nervous system cell and then separating a glycoprotein having N-acetylglucosamine at a non-reducing terminal thereof.