The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 18, 2018
Filed:
Jul. 16, 2015
Applicant:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Inventors:
Douglas S. Watson, Harrisonburg, VA (US);
Allison D. Ortigosa, Harrisonburg, VA (US);
Michael A. Rauscher, Garwood, NJ (US);
Kathryn M. Story, Harrisonburg, VA (US);
Assignee:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
B01D 15/18 (2006.01); C07K 14/62 (2006.01); B01D 15/32 (2006.01); B01D 15/36 (2006.01); C07K 1/18 (2006.01); C07K 1/20 (2006.01); B01D 15/38 (2006.01);
U.S. Cl.
CPC ...
C07K 14/62 (2013.01); B01D 15/1878 (2013.01); B01D 15/327 (2013.01); B01D 15/363 (2013.01); B01D 15/3847 (2013.01); C07K 1/18 (2013.01); C07K 1/20 (2013.01);
Abstract
A process is described for purifying insulin and insulin analogs that comprises use of two or more orthogonal chromatographic purification steps in tandem following enzymatic digestion of the propeptide-insulin precursor to remove specific product impurities, improve process consistency, and increase process redundancy in the purification of the insulin or insulin analog, e.g., insulin lispro.