The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 18, 2018
Filed:
Aug. 13, 2015
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangdong, CN;
Xiaoyun Lu, Guangzhou, CN;
Jian Tang, Guangzhou, CN;
Ke Ding, Guangzhou, CN;
Tianyu Zhang, Guangzhou, CN;
Xiantao Zhang, Guangzhou, CN;
Zhengchao Tu, Guangzhou, CN;
Tian Wu, Guangzhou, CN;
Junting Wan, Guangzhou, CN;
Yuanyuan Cao, Guangzhou, CN;
Shengjiang He, Guangzhou, CN;
Guangzhou Eggbio Co., Ltd., Guangzhou, CN;
Abstract
Disclosed in the disclosure are a pyrazolo [1,5-a] pyrideine compound with structural features as shown in formula (I) or a pharmaceutically acceptable salt, stereoisomer or prodrug molecule thereof and a use thereof. Such compounds have a good in vitro antituberculosis activity, and the minimal inhibitory concentration (MIC) of the compounds is lower than 0.1 μg/mL and partially achieves 0.01 μg/mL, and have a very strong inhibiting effect on clinically selected multi-drug resistant tuberculosis (MDR-TB) strains. In an in vivo experiment, the pyrazolo[1,5-a] pyrideine compounds of the present disclosure can effectively scavenge the infectious dose of H37Ra in a mouse body at 20 mg/kg/d does, thereby being a new type of antituberculosis compound.