The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 04, 2018
Filed:
Apr. 10, 2017
Drexel University, Philadelphia, PA (US);
Baruch S. Blumberg Institute, Doylestown, PA (US);
Ju-Tao Guo, Lansdale, PA (US);
Jinhong Chang, Chalfont, PA (US);
Timothy M. Block, Doylestown, PA (US);
William A. Kinney, Newtown, PA (US);
Harold R. Almond, Maple Glen, PA (US);
Drexel University, Philadelphia, PA (US);
Baruch S. Blumberg Institute, Doylestown, PA (US);
Abstract
The present invention provides small molecule inhibitors of hepatitis B virus (HBV) covalently closed circular (ccc) DNA, which are useful as therapeutics in the management of chronic HBV. The compounds of the invention achieve epigenetic modification of the cccDNA, histone modification and histone deacetylase activity inhibition, thus modulating HBV cccDNA. The present invention further provides methods for modulating HBV cccDNA, for treating or preventing HBV in a subject, and for modulating cccDNA transcription of hepatitis B in a subject.