The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 2018
Filed:
Jul. 22, 2015
Danisco Us Inc., Palo Alto, CA (US);
The Goodyear Tire & Rubber Company, Akron, OH (US);
Zachary Q. Beck, Palo Alto, CA (US);
Michael C. Miller, Palo Alto, CA (US);
Caroline M. Peres, Palo Alto, CA (US);
Yuliya A. Primak, Menlo Park, CA (US);
Jeff P. Pucci, Pacifica, CA (US);
Derek H. Wells, Palo Alto, CA (US);
Danisco US Inc., Palo Alto, CA (US);
The Goodyear Tire & Rubber Company, Akron, OH (US);
Abstract
The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms by engineering a microorganism for increased carbon flux towards mevalonate production in the following enzymatic pathways: (a) citrate synthase, (b) phosphotransacetylase, (c) acetate kinase, (d) lactate dehydrogenase, (e) malic enzyme, and (f) pyruvate dehydrogenase such that one of more of the enzyme activity is modulated. In addition, production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids can be further enhanced by the heterologous expression of the mvaE and mvaS genes (such as, but not limited to, mvaE and mvaS genes from the organismsDSM 20601,EG2, and).