The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 20, 2018
Filed:
Aug. 04, 2014
Asymchem Laboratories (Tianjin) Co., Ltd., Tianjin, CN;
Asymchem Life Science (Tianjin) Co., Ltd., Tianjin, CN;
Tianjin Asymchem Pharmaceutical Co., Ltd., Tianjin, CN;
Asymchem Laboratories (Fuxin) Co., Ltd., Fuxin, CN;
Jilin Asymchem Laboratories Co., Ltd., Dunhua, CN;
Asymchem Laboratories (Tianjin) Co., Ltd, Tianjin, CN;
Asymchem Life Science (Tianjin) Co., Ltd, Tianjin, CN;
Tianjin Asymchem Pharmaceutical Co., Ltd, Tianjin, CN;
Asymchem Laboratories (Fuxin) Co., Ltd, Fuxin, CN;
Jilin Asymchem Laboratories Co., Ltd, Dunhua, CN;
Abstract
The application provides a Diketoreductase (DKR) mutant, its nucleotide coding sequence, and an expression cassette, recombinant vector and host cell containing the sequence, as well as a method for application of the mutant to the preparation of 3R,5S-dicarbonyl compound. An ee value of the obtained 3R,5S-dicarbonyl compound is higher than 99%, and a de value is about 90%. The DKR mutant is a key pharmaceutical intermediate, and particularly provides an efficient catalyst for synthesis of a chiral dicarbonyl hexanoic acid chain of a statin drug.