The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2018
Filed:
Jan. 09, 2017
Applicant:
Taro Pharmaceutical Industries Ltd., Haifa Bay, IL;
Inventors:
Simon Cherniak, Haifa, IL;
Rosa Cyjon, Haifa, IL;
Ilana Ozer, Yokneam, IL;
Igor Nudelman, Haifa, IL;
Assignee:
Taro Pharmaceutical Industries Ltd., Haifa Bay, IL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07J 5/00 (2006.01); C07J 7/00 (2006.01); C07J 75/00 (2006.01); C07J 71/00 (2006.01);
U.S. Cl.
CPC ...
C07J 7/009 (2013.01); C07J 5/0023 (2013.01); C07J 5/0038 (2013.01); C07J 5/0076 (2013.01); C07J 7/008 (2013.01); C07J 71/0015 (2013.01); C07J 75/00 (2013.01); H05K 999/99 (2013.01);
Abstract
The present invention provides an improved process for the preparation of 17-desoxy corticosteroid derivatives in a single chemical step by reacting the 17-hydroxy starting material with an excess of Trimethylsilyl Iodide. The present invention is specifically advantageous in preparing 17-desoxy corticosteroid derivatives having one or more halogen groups at positions 2, 6, 7 or 9 of the corticosteroid such as Clocortolone of Desoximetasone.