The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 30, 2018
Filed:
Apr. 21, 2014
Kunming Institute of Botany, the Chinese Academy of Sciences, Kunming, Yunnan, CN;
The Key Laboratory of Chemistry for Natural Product of Guizhou Province & Chinese Academy of Science, Guiyang, Guizhou, CN;
Shanghai Institutes for Biological Sciences, Cas, Shanghai, CN;
Institute of Zoology, Chinese Academy of Sciences, Beijing, CN;
Xiaojiang Hao, Yunnan, CN;
Chen Yan, Guizhou, CN;
Haiyang Liu, Yunnan, CN;
Lin Li, Shanghai, CN;
Xiaoli He, Shanghai, CN;
Quan Chen, Beijing, CN;
Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, Yunnan, CN;
The Key Laboratory of Chemistry for Natural Product of Guizhou Province and Chinese Academy of Science, Guiyang, Guizhou, CN;
Shanghai Institutes of Biological Sciences, CAS, Shanghai, CN;
Institute of Zoology, Chinese Academy of Sciences, Beijing, CN;
Abstract
The invention relates to a derivative of 15-oxospiramilacton, particularly to a compound of Formula I or II, or an isomer, a solvate or a pharmaceutically acceptable salt thereof. The invention also relates to a pharmaceutical composition comprising the compound as pharmaceutically active ingredient, a method for preparing the same, and use thereof in manufacture of an anti-tumor agent. The derivative of 15-oxospiramilactone of the invention have an activity against multiple tumor cell lines, and the anti-tumor activity is positively correlated to an activity inhibiting the Wnt signaling pathway.