The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 16, 2018
Filed:
Apr. 21, 2004
David Epstein, Huntington, NY (US);
Dilara Grate, Waltham, MA (US);
Martin Stanton, Stow, MA (US);
John L. Diener, Cambridge, MA (US);
Charles Wilson, Concord, MA (US);
Thomas Greene Mccauley, Somerville, MA (US);
Errol Desouza, Cambridge, MA (US);
David Epstein, Huntington, NY (US);
Dilara Grate, Waltham, MA (US);
Martin Stanton, Stow, MA (US);
John L. Diener, Cambridge, MA (US);
Charles Wilson, Concord, MA (US);
Thomas Greene McCauley, Somerville, MA (US);
Errol Desouza, Cambridge, MA (US);
Archemix LLC, Cambridge, MA (US);
Abstract
Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.